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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, provided that they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes established that patients had a normal weight loss of four years old.1% rather than participants have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to lose weight naturally can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you should err to the side of caution and allow FDA do its job and demand some study be done in order that the public recognizes the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on their own medications.

    Researchers found that participants using this drug for the year, lost weight within one month and have kept the extra weight off throughout the 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, which may make them more efficient and safer.

    Combo-pilling will be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that since right now there are no long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartrate, and really should not be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, along with by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

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