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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence in accordance with a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err on the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on the medications.

Researchers found out that participants taking this drug to get a year, dropped excess weight within four weeks and have kept the load off throughout the 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which can make them more effective and safer.

Combo-pilling may be the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular may be the fact that by right now there aren't any long term prescription weightloss pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug could also raise hypertension and heartrate, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside the liver shortly after uptake in the intestines and it has no therapeutic effect. Buprenorphine may be the active substance; it's absorbed beneath the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who have had gastric bypass, the location where the first the main intestine is bypassed and the stomach contents empty right into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy in which the drug is taken up with the duodenum and transferred straight away to the liver by the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken up by portions of the intestine that are not served through the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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