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Evidence is increasing that most addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err assisting caution and permit the FDA do its job and demand some study be done so that the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on the medications.

Researchers found out that participants taking this drug for the year, dropped excess weight within a month and have kept the weight off through the entire 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them more effective and safer.

Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that as of right now there are no long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure levels and pulse rate, and shouldn't be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

Approving a drug using this type of many potentially lethal negative effects is inconsistent while using mission statement from the FDA. The power from the drug manufacturing lobby is blatantly evident inside the approval of many drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety in the US.

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