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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight loss in addition to a reduced-calorie diet and exercising.

Using two separate drugs to lose weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you should err along the side of caution and let the FDA do its job and demand some study be done in order that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to make money and that they would say everything to keep people on his or her medications.

Researchers discovered that participants investing in this drug for the year, dropped excess weight within 4 weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them more effective and safer.

Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular may be the fact that at the time of right now there are not any long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure level and pulse rate, and really should not be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not be used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.

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