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  • Evidence is increasing that most addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This section of the problem regulates reward responses in establishing food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both once they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err to the side of caution and allow FDA do its job and demand some study be done so that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on the medications.

    Researchers discovered that participants investing in this drug for any year, dropped a few pounds within a month and have kept the load off during the entire 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, that might make them more effective and safer.

    Combo-pilling may be the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA.

    Seizures certainly are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure levels and heartrate, and shouldn't be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure level and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    Approving a drug using this many potentially lethal unwanted side effects is inconsistent while using mission statement of the FDA. The power from the drug manufacturing lobby is blatantly evident within the approval of numerous drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside US.

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